Select a region with no data or Coffee is the primary source of caffeic acid in the human diet. Both are part of the carbocyclic carboxylic acid group.[2]. FAQ; Credits; More documentation; Caffeic acid. The purpose of the fee is to recover costs associated It is also known as an antioxidant in vitro and also in vivo. [19] Oral administration of high doses of caffeic acid in rats has caused stomach papillomas. Caffeic acid has been shown to inhibit carcinogenesis, although other experiments show possiblecarcinogenic effects. No significant effect was noted otherwise. Caffeic acid has been shown to act as a carcinogenic inhibitor. Technology, Office of Data It is found in all plants because it is a key intermediate in the biosynthesis of lignin, one of the principal components of woody plant biomass and … Caffeic Acid is still listed under older Hazard Data sheets [8] as a potential carcinogen because of two early experiments on rats and mice. [22][23] Other than caffeic acid being a thiamine antagonist (antithiamine factor), there have been no known ill effects of caffeic acid in humans. shall not be liable for any damage that may result from jcamp-dx.js and ", "Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4-methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term multi-organ carcinogenesis model", "Agents Classified by the IARC Monographs", "Caffeic acid metabolism by gnotobiotic rats and their intestinal bacteria", "Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats", "A Use for that Last Cup of Coffee: Film and Paper Development",, Creative Commons Attribution-ShareAlike License, 223 to 225 °C (433 to 437 °F; 496 to 498 K), 327 nm and a shoulder at c. 295 nm in acidified methanol, This page was last edited on 23 October 2020, at 03:56. Find out how LUMITOS supports you with online marketing. [3], Caffeic acid and its derivative caffeic acid phenethyl ester (CAPE) are produced in many plants including: pears, basil, thyme, verbena, tarragon, oregano, wood betony, burning bush, turmeric, dandelion, yarrow, horsetail, rosemary, hawthorn and coffee. It is related to cinnamic acid, but it has two hydroxyl groups not found in cinnamic acid. Both caffeic acid and chlorogenic acid are found in coffee beans. [13], Another study also showed that CAPE suppresses acute immune and inflammatory responses and holds promise for therapeutic uses to reduce inflammation. [4] It can also be found in the freshwater fern Salvinia molesta[5] and in the mushroom Phellinus linteus. Caffeic acid can be esterified with quinic acid to form chlorogenic acid. jcamp-plot.js. [11][12][13], Dihydroxyphenylalanine ammonia-lyase was presumed to use 3,4-dihydroxy-L-phenylalanine (L-DOPA) to produce trans-caffeate and NH3. Data from NIST Standard Reference Database 69: The National Institute of Standards and Technology (NIST) and Informatics, NIST / TRC Web Thermo Tables, professional edition (thermophysical and thermochemical data), NIST Mass Spectrometry Data Center, William E. Wallace, director, Modified by NIST for use in this application. All mass spectra in this site (plus many more) are [17], Caffeic acid is an antioxidant in vitro and also in vivo. Oral administration of high doses of caffeic acid in rats has caused stomach papillomas, leading to the perception of caffeic acid as carcinogenic.

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