mutation that have been observed in samples for this gene. SPARC Is a Key Regulator of Proliferation, Apoptosis and Invasion in Human Ovarian Cancer Abstract. separate page. Its divergent actions reflect the complexity of this protein, because in certain types of cancers, such as melanomas and gliomas, SPARC is associated with a highly aggressive tumor phenotype, while in others, mainly ovarian, neuroblastomas and colorectal cancers, SPARC may function as a tumor suppressor. HHS original, unfiltered display. the ChromoView page (to view CNVs across the whole chromosome), the COSMIC panel on the left. Genome Browser and Ensembl. Albumin-Modified Melanin-Silica Hybrid Nanoparticles Target Breast Cancer Cells via a SPARC-Dependent Mechanism. To our knowledge, there is no single study conducted on the role of secreted protein acidic and rich in cysteine (SPARC) gene polymorphism in breast cancer risk or prognosis. displayed. For more detailed information about copy number data and gain/loss definitions click here. help pages.
Osteonectin is a glycoprotein in the bone that binds calcium.
Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis. data, check this box. Br J Cancer. as 'pathogenic', or 'neutral' if the score is ≤ 0.5. You can see additional information about this data in the help pages. samples with that type of mutation. The secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin or basement-membrane protein 40 (BM-40), is an extracellular matrix glycoprotein that is implicated in the metastatic potential of several cancer types . help pages. The graphical view can be switched to cDNA coordinates Many probes fall outside of coding regions and are not displayed given under the table. For some TCGA samples where minor allele information is not available the average ploidy value could not be calculated. The table currently shows only high value (numeric) copy number data. This default peptide view shows a histogram of single base These ids are maintained to help track existing mutations. full length of the gene by default. Use the range slider to set the general start and end coordinates for Get the latest research from NIH: https://www.nih.gov/coronavirus. Some copy number data is descriptive with no associated numeric more information in our Markov models. Its divergent actions reflect the complexity of this protein, because in certain types of cancers, such as melanomas and gliomas, SPARC is associated with a highly aggressive tumor phenotype, while in others, mainly ovarian, neuroblastomas and colorectal cancers, SPARC may function as a tumor suppressor. selection(s). button. Recently, SPARC has generated considerable interest as a multi-faceted protein that belongs to a family of matricellular proteins.
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